The use of Gameshark 5.0 with PSX ISOs offered several benefits. Firstly, it enabled gamers to play their favorite PSX games without the need for the original discs, which could be lost, damaged, or hard to find. Secondly, it provided access to a vast library of games, as gamers could obtain and play ISO versions of their favorite titles. Additionally, the device allowed for the use of cheats and codes, enhancing gameplay by enabling features like infinite lives, unlimited ammo, or the ability to access locked levels.